CAS 1140909-48-3: cabozantinib (S)-malate
Formula:C28H24FN3O5·C4H6O5
InChI:InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1
InChI key:InChIKey=HFCFMRYTXDINDK-WNQIDUERSA-N
SMILES:C(NC1=CC=C(OC=2C3=C(C=C(OC)C(OC)=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4.[C@H](CC(O)=O)(C(O)=O)O
Synonyms:- (2S)-2-Hydroxybutanedioic acid compd.with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide(1:1)
- (2S)-2-hydroxybutanedioic acid
- Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
- Cabozantinib L-(-)-Apple Acid
- Cabozantinib L-Malate
- Cabozantinib Malate
- Cometriq
- N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
- N1-[4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N1'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- Xl 184
- Cabozantinib S-malate
- See more synonyms
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Found 10 products.
Cabozantinib malate
CAS:Inhibits MET, VEGFR1, VEGFR2; VEGFR3 receptor tyrosine kinases; antineoplasticFormula:C28H24FN3O5·C4H6O5Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:635.6 g/molCabozantinib S-malate
CAS:Cabozantinib S-malate (XL184) is the salt form of cabozantinib, an orally bioavailable, small molecule RTK inhibitor with potential antineoplastic activity.Formula:C32H30FN3O10Purity:100% - 99.41%Color and Shape:SolidMolecular weight:635.59Cabozantinib (S)-Malate
CAS:Formula:C28H24FN3O5·C4H6O5Color and Shape:White To Off-White SolidMolecular weight:501.51 134.09Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
CAS:Formula:C32H30FN3O10Purity:98%Color and Shape:SolidMolecular weight:635.5931Cabozantinib malate
CAS:Formula:C32H30FN3O10Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:635.59Cabozantinib L-Malate Salt
CAS:Controlled ProductApplications Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),Formula:C28H24FN3O5·C4H6O5Color and Shape:NeatMolecular weight:635.59Cabozantinib (Phenylene-d4) L-Malate Salt
CAS:Controlled ProductApplications Cabozantinib-d4 L-Malate Salt, is the labeled analogue of Cabozantinib L-Malate Salt (C051500), which is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and has been shown to reduce tumor growth, metastasis, and angiogenesis. References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),Formula:C28D4H20FN3O5·C4H6O5Color and Shape:NeatMolecular weight:639.62
![Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000AJ8.jpg&w=3840&q=75)
