CAS 1149-99-1: illudin S
Formula:C15H20O4
InChI:InChI=1S/C15H20O4/c1-8-10-9(6-13(2,7-16)12(10)18)11(17)14(3,19)15(8)4-5-15/h6,12,16,18-19H,4-5,7H2,1-3H3/t12-,13+,14+/m1/s1
InChI key:InChIKey=DDLLIYKVDWPHJI-RDBSUJKOSA-N
SMILES:CC=1C2(CC2)[C@@](C)(O)C(=O)C=3C1[C@@H](O)[C@@](CO)(C)C3
Synonyms:- (2'S,3'R,6'R)-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-2',3'-dihydrospiro[cyclopropane-1,5'-inden]-7'(6'H)-one
- (2′S,3′R,6′R)-2′,3′-Dihydro-3′,6′-dihydroxy-2′-(hydroxymethyl)-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-[5H]inden]-7′(6′H)-one
- 2',3'-Dihydro-2',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethylspiro(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one
- Brn 2336420
- Ccris 3540
- Dr-15978
- Illudine S
- Lampterol
- Lunamycin
- Nsc 400979
- Nsc 626369
- See more synonyms
Sort by
Found 3 products.
Illudin S
CAS:Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties.Formula:C15H20O4Purity:98.15%Color and Shape:SolidMolecular weight:264.32llludin S
CAS:Illudin S is a sesquiterpene toxin, which is a naturally occurring compound isolated from several species of fungi belonging to the genus Omphalotus, such as Omphalotus olearius, commonly known as the Jack-o'-lantern mushroom. Its mode of action involves alkylating DNA, which leads to DNA cross-linking and subsequent inhibition of DNA synthesis. This mechanism renders it highly cytotoxic, as it can induce cell death by disrupting normal cellular replication processes. While its toxicity limits its direct therapeutic application, Illudin S has served as a valuable lead compound for the development of potential anticancer agents. Derivatives of Illudin S, such as Irofulven, have been modified to enhance selective toxicity towards cancer cells while reducing adverse effects on healthy tissues. These derivatives can exploit the differential repair mechanisms between cancer cells and normal cells, allowing for targeted cancer therapy. Illudin S and its derivatives are also used extensively in biochemical research to study mechanisms of DNA damage and repair, offering insights into cellular responses to genotoxic stress. This research has broader implications for understanding cancer biology and developing novel therapeutic strategies.Formula:C15H20O4Purity:Min. 95%Molecular weight:264.13616
