CAS: 115532-49-5

[6-(Dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium is a synthetic compound that can be used to treat cancer. It is a mitochondrial inhibitor that blocks the production of ATP by inhibiting the mitochondrial electron transport chain. This inhibits cellular respiration, leading to cell death. This agent has been shown to inhibit choroidal neovascularization in rats and mice by inhibiting angiogenesis and vascular permeability. This agent has also been shown to protect against neuronal damage in rat brain tissue following radiation exposure. The structure of this compound contains two azanyl groups that can be reduced with potassium ion, which may account for its low energy radiation properties.

TMRM is a cell-permeant cationic lipophilic red fluorescent dye (λex: 530 nm, λem: 592 nm).