15R-Bimatoprost is a synthetic prostaglandin analog primarily used in ophthalmology for the treatment of glaucoma and ocular hypertension. It functions by increasing the outflow of aqueous humor, thereby reducing intraocular pressure. The compound is characterized by its ability to mimic the action of natural prostaglandins, promoting the relaxation of the ciliary muscle and enhancing fluid drainage from the eye. Structurally, it features a long hydrocarbon chain with specific functional groups that contribute to its biological activity. Bimatoprost is known for its potency and selectivity, making it effective in lowering intraocular pressure. Additionally, it has been studied for its potential effects on eyelash growth, leading to its use in cosmetic applications. The substance is typically administered as an eye drop solution and is well-tolerated, although some users may experience side effects such as ocular hyperemia or changes in eyelash pigmentation. Overall, 15R-Bimatoprost represents a significant advancement in the management of eye conditions related to elevated intraocular pressure.

15R-Bimatoprost

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15-epi Bimatoprost

15-epi Bimatoprost ((15R)-Bimatoprost)

Applications An intermediate in the production of Bimatoprost (B386800).


(15R)-Bimatoprost

(15R)-Bimatoprost is a prostaglandin analogue that is used to treat glaucoma. It is an esterification of the corresponding acid with 15-deoxy-Δ12,14-prostaglandin J2 (PGD2), which is a metabolite of prostaglandin F2α (PGF2α). The esterification reaction requires an alcohol, such as methanol or ethanol, and a carboxylic acid chloride to react with the PGD2. This synthesis can be accomplished using a convergent approach that involves one or more reagents, including phenylsulfone and olefination. Other analogues of bimatoprost include travoprost and latanoprost.

"(15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide), an isomer of Bimatoprost characterized by an inverted (β) hydroxyl group on C-15 [1], is a prostaglandin analog employed in the treatment of glaucoma and ocular hypertension."

CAS 1163135-92-9: 15R-Bimatoprost

15-epi Bimatoprost

Ref: ST-EA-CP-B40004

15-epi Bimatoprost ((15R)-Bimatoprost)

Ref: 4Z-B-244

(15R)-Bimatoprost

Ref: TR-B386815

(15R)-Bimatoprost

Ref: 3D-FB18597

(15R)-Bimatoprost

Ref: TM-T84512