CAS 1169562-71-3: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride (1:?)

Stability Hygroscopic Applications XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Koltun, E., et al.: Bioorg. Med. Chem. Lett., 22, 3727 (2012)

BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215

XL413 hydrochloride is a potent small-molecule inhibitor, which is a synthetic compound specifically designed to target protein kinases. It acts as a selective inhibitor of Cdc7 kinase, a serine/threonine kinase essential for the initiation of DNA replication. This kinase is involved in the phosphorylation of MCM2 and the activation of the pre-replicative complex, a critical step in the S-phase of the cell cycle. By inhibiting Cdc7, XL413 hydrochloride effectively halts cell cycle progression, thereby impacting cellular proliferation. The primary application of XL413 hydrochloride is in the field of cancer research. It is particularly valuable in studies exploring the cell cycle and DNA replication mechanisms, offering insights into potential therapeutic avenues for cancer treatment where dysregulated cellular division is a hallmark. Researchers utilize this compound to investigate tumor cell lines and assess the effects of kinase inhibition on cancer cell growth, survival, and replication dynamics. Its ability to selectively inhibit Cdc7 makes it a crucial tool for scientists aiming to develop targeted cancer therapies.