PKI 402, with the CAS number 1173204-81-3, is a chemical compound that functions primarily as a selective inhibitor of protein kinase activity. It is particularly noted for its role in inhibiting the activity of certain kinases involved in cellular signaling pathways, which can influence various biological processes such as cell growth, differentiation, and apoptosis. The compound is often utilized in research settings to study the effects of kinase inhibition on cellular functions and to explore potential therapeutic applications in diseases characterized by dysregulated kinase activity, such as cancer. PKI 402 exhibits a specific binding affinity for its target kinases, making it a valuable tool in pharmacological studies. Its chemical structure includes functional groups that contribute to its inhibitory properties, and it is typically administered in controlled laboratory environments. As with many chemical inhibitors, understanding its pharmacokinetics and potential off-target effects is crucial for its application in both research and potential therapeutic contexts.

PKI 402

1173204-81-3: 1-[4-[3-Ethyl-7-(morpholin-4-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl]-3-[4-[(4-methylpiperazin-1-yl)carbonyl]phenyl]urea, PKI-402

PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.

PKI-402

PKI 402 is a potent enzyme inhibitor, which is derived synthetically to target specific kinase activities. The product's source involves sophisticated chemical synthesis techniques designed to enhance selectivity and potency. PKI 402 functions primarily by modulating protein kinase activities, inhibiting phosphorylation processes crucial in cell signaling pathways.

This compound is widely utilized in research focusing on cell signaling, oncology, and molecular biology, providing insights into kinase-driven cellular mechanisms. Its applications extend to studying signal transduction pathways, exploring therapeutic avenues for kinase-related diseases, and elucidating biochemical cascades implicated in cancer progression. PKI 402 serves as a vital tool for probing the intricate networks of kinase regulation and offers potential leads for drug development in targeting proliferative diseases. Scientists utilize this inhibitor to delineate cellular responses, offering a window into the dynamic regulation of cellular physiology and pathophysiology.

CAS 1173204-81-3: PKI 402

PKI-402

Ref: TM-T3656

PKI-402

Ref: 54-BUP10661

PKI 402

Ref: 3D-YWB20481