CAS 117464-70-7: 2',7'-bis(2-carboxyethyl)-5(6)-*carboxyfluorescei

BCECF-AM, a compound permeable to cell membranes, serves as a fluorescent indicator for monitoring intracellular pH levels.

2',7'-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester Mixed isomers (BCECF) is a fluorescent probe that can be used to measure the mitochondrial membrane potential. BCECF has been shown to have a high affinity for the acidic environment of the mitochondria, and it accumulates in cells with low mitochondrial membrane potentials. BCECF has been used to study the effect of apoptosis on tumor cells, as well as in other studies of cell death and survival. It has also been used to study the effects of transplants on cardiac tissue. The BCECF probe is often used in conjunction with other probes that emit at different wavelengths, such as tetramethylrhodamine ethyl ester (TMR).

2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester (BCECF) is a fluorescent probe that has been extensively used in biological and medical research. It can be used as an indicator of the mitochondrial membrane potential and as a measure of photosynthetic activity. BCECF is also used to assess the cellular response to epidermal growth factor, which is involved in cell proliferation. BCECF has also been shown to be useful in clinical studies involving trabeculectomy, a surgical procedure for glaucoma. This probe has been shown to bind to pyrazole rings present in the active site of group P2 enzymes, such as bacterial DNA gyrase and RNA polymerase.