CAS: 1181081-71-9

CLP257 is a synthetic compound characterized as an inhibitor of chloroplastic RNA polymerase. It is derived from a systematic chemical synthesis process involving the rational design of inhibitory molecules targeting chloroplastic transcriptional machinery. This product acts by binding to the RNA polymerase complex, effectively disrupting the transcription process within chloroplasts. The inhibition occurs through allosteric modulation, where CLP257 induces conformational changes that impede the enzyme's ability to synthesize RNA. In the realms of genetic and botanical research, CLP257 is employed to study chloroplast gene expression and its regulatory pathways. By selectively inhibiting RNA polymerase, researchers can delineate the role of chloroplast-encoded genes in photosynthesis and other essential plant processes. Additionally, it serves as a tool for dissecting the intricacies of chloroplastic RNA polymerase's structural and functional dynamics. The compound's utility extends to experimental setups aiming at understanding the impact of transcriptional inhibition on chloroplast-to-nucleus signaling and its subsequent effects on plant growth and development.

CLP257

CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.