CAS: 1184136-10-4

UNC-926 is a synthetic molecule that can act as a transcriptional regulator. It interacts with lysine residues in the regulatory proteins of pluripotent stem cells, which are responsible for the regulation of their activity. This interaction leads to conformational changes in the protein, which in turn affects its ability to regulate gene expression. UNC-926 has been shown to be active against viruses such as HIV and influenza A virus. In addition, it has been shown to inhibit the replication of these viruses by methylating specific sites on chromatin-bound DNA. UNC-926 is also a potent inhibitor of methyltransferase enzymes, which are involved in post-translational modifications of immunodeficiency regulatory proteins (IRP). It inhibits methylation at specific sites on IRP molecules and prevents them from binding to RNA polymerase II and III, inhibiting transcription of viral genes.

UNC926 inhibits L3MBTL1 (IC50: 3.9 μM), has affinity for L3MBTL3, blocks 3xMBT-H4K20me1 interactions, doesn't affect 53BP1-H4K20me1 binding.

UNC926