CAS 118414-82-7: MK-886

MK-886 is a synthetic compound, formally classified as a leukotriene biosynthesis inhibitor, which is derived through chemical synthesis processes. This compound acts by specifically targeting the 5-lipoxygenase-activating protein (FLAP), a crucial component in the leukotriene synthesis pathway. By inhibiting FLAP, MK-886 effectively suppresses the production of leukotrienes, which are lipid compounds that play a pivotal role in the inflammatory response. The applications of MK-886 are significant in research settings, particularly in the study of inflammatory diseases and disorders related to leukotriene production. It has been utilized as a tool in various experimental models to elucidate the mechanisms underpinning conditions such as asthma, arthritis, and certain allergic reactions. Moreover, MK-886 has been explored for its potential role in cancer research, investigating how modulating inflammatory pathways could impact tumorigenesis and metastasis. Despite its utility in experimental systems, MK-886 is typically utilized in laboratory research rather than clinical settings.

Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1. References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

MK-886

MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).

MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase. MK 886 is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.