CAS: 1185241-19-3

Applications (E)-Isomer of labelled Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian. References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Entacapone-d10 is a prodrug that is converted to the active form, entacapone, in the body by hydrolysis. Entacapone-d10 is used for the treatment of Parkinson's disease and belongs to a class of drugs called catechol-O-methyltransferase (COMT) inhibitors. Monitoring entacapone-d10 in urine enables one to assess its bioequivalence with other products containing entacapone. Entacapone-d10 has been shown to be an effective drug for Parkinson's disease with a favorable side effect profile. The nature and environment of this product are not known.