Phosphorothioic acid, O,O,S-triethyl ester, commonly known as triethyl phosphorothioate, is an organophosphorus compound characterized by its phosphorus atom bonded to three ethyl groups and a thiol group. This compound is typically a colorless to pale yellow liquid with a faint odor. It is soluble in organic solvents but has limited solubility in water. As an organophosphate, it exhibits properties that can affect biological systems, particularly as an inhibitor of acetylcholinesterase, which is crucial for nerve function. This characteristic makes it relevant in both agricultural applications as a pesticide and in toxicological studies. The compound is also known for its potential environmental persistence and toxicity to non-target organisms, necessitating careful handling and regulation. Safety data sheets indicate that it may pose risks through inhalation, skin contact, or ingestion, highlighting the importance of using appropriate protective measures when working with this substance. Overall, triethyl phosphorothioate is significant in both industrial and research contexts, particularly in the fields of chemistry and environmental science.

Phosphorothioic acid, O,O,S-triethyl ester

1186-09-0: Ethyl phosphorothioate ((EtO)<sub>2</sub>(EtS)PO), Ethyl thiophosphate ((EtO)<sub>2</sub>(EtS)PO), O,O,S-Triethyl phosphorothiolate, O,O,S-Triethyl thiophosphate, O,O,S-Triethylphosphorothiolate, O,O-Diethyl S-ethyl phosphorothioate, Phosphorothioic acid, O,O,S-triethyl ester, Thiophosphoric acid O,O,S-triethyl ester, Triethyl phosphorothioate, Ethyl phosphorothioate ((EtO)2(EtS)PO), O,O,S-Triethyl phosphorothioate, Ethyl thiophosphate ((EtO)2(EtS)PO)

O,O,S-Triethyl phosphorothioate is a pesticide that inhibits the growth of insects by binding to the active site of the enzyme acetylcholinesterase. It is used in agriculture as a synergist with piperonyl butoxide (PBO) for protection against pests such as termites and cockroaches. Triethyl phosphorothioate has been shown to cause lung damage in rats when given at high doses. The relevance of this finding to humans is not clear. It may be due to its ability to generate reactive oxygen species and lipid peroxidation products in tissues. This effect can be prevented by giving animals PBO pre-treatment or by using lower doses of triethanolamine phosphorothioate.

O,O,S-Triethyl phosphorothioate

Applications O,O,S-Triethyl Phosphorothiolate, is shown to have Morphogenesis and toxicological lung damage in rats. It is also an organophosphorus used as a pesticide.
References Ishizaki, S., et al.: Nippon Jui Chikusan Daigaku Kenkyu Hokoku, 37, 88 (1988); Kjoelholt, J., et al.: Chemosphere, 14, 1763 (1985);


CAS 1186-09-0: Phosphorothioic acid, O,O,S-triethyl ester

O,O,S-Triethyl phosphorothioate

Ref: 3D-BAA18609

O,O,S-Triethyl Phosphorothiolate

Ref: TR-T777015