CAS 1191-85-1: 5,8,11,14-eicosatetraynoic acid

ETYA is an angiotensin II receptor antagonist that binds to the angiotensin II type 1 receptor. It has been shown to prevent the activation of the angiotensin system, which is responsible for vasoconstriction and other pathogenic mechanisms. ETYA has been shown to have a protective effect against infectious diseases in vivo, including Streptococcus pneumoniae, Salmonella typhimurium, and Listeria monocytogenes. ETYA has also shown efficacy as a treatment for granule neuron disease (GND) in CD-1 mice by inhibiting arachidonic acid metabolism and preventing calcium release from intracellular stores. ETYA is also able to inhibit cyclase and protease activities in vitro.

A cyclooxygenase, lipoxygenase and cytochrome P450 inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).