CAS 119168-77-3: Tebufenpyrad

Tebufenpyrad (Comanche) (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant

Tebufenpyrad is a fungicide with acylation activity. It is also a matrix effect modifier and synergist for other fungicides, such as thiophanate-methyl, chlorothalonil, and propiconazole. Tebufenpyrad is used in the treatment of plant diseases caused by fungi that are resistant to other fungicides. Tebufenpyrad has been shown to be an effective fungicide against strains of fungi resistant to other chemical classes of fungicides. Tebufenpyrad inhibits the synthesis of DNA by binding to the enzyme RNA polymerase II, which prevents transcription and replication. The inhibition of RNA polymerase II leads to a reduction in mRNA synthesis, disrupting protein synthesis and cell division. This product also has genotoxic activity, which may be due to its ability to induce apoptosis.

Applications Tebufenpyrad is a pyrazole acaricide and insecticide commonly used in commercial greenhouses. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tomera, J., et al.: J. Food Sci. Technol., 10, 129 (1999), Zhang, K., et al.: J. Agric. Food Chem., 57, 4019 (2009), Cus, F., et al.: Food Control., 21, 1512 (2010),