Defensin HNP-2, also known as human neutrophil peptide 2, is a member of the defensin family, which are small cationic peptides that play a crucial role in the innate immune response. This peptide is primarily produced by neutrophils and exhibits antimicrobial properties, effectively targeting a broad range of pathogens, including bacteria, fungi, and viruses. HNP-2 is characterized by its compact structure, which includes a series of disulfide bonds that stabilize its conformation, allowing it to interact with microbial membranes. The peptide is positively charged, which facilitates its binding to negatively charged microbial surfaces, leading to membrane disruption and cell lysis. Additionally, defensins like HNP-2 are involved in modulating immune responses, attracting immune cells to sites of infection, and promoting wound healing. Its role in host defense makes it a subject of interest in research related to infectious diseases and potential therapeutic applications. The CAS number 120721-97-3 uniquely identifies this specific peptide in chemical databases.

Defensin HNP-2 (human)

120721-97-3: H-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH (Disulfide bonds between Cys1 and Cys29/Cys3 and Cys18/ Cys8 and Cys28)

Defensin HNP-2 is a peptide that has been shown to bind to cancer cells, metabolic disorders, and endometriosis. It also has pharmaceutical preparations for treating microbial infection and other diseases. Defensin HNP-2 is a broad-spectrum antimicrobial peptide and it binds to bacterial membranes in the cell cytoplasm. Defensin HNP-2 may be used as diagnostic agents or in the treatment of microbial infections. This antimicrobial peptide is stable when complexed with calcium ions and can be used against s. aureus strains that are resistant to antibiotics such as ciprofloxacin.

CAS 120721-97-3: Defensin HNP-2 (human)

Defensin HNP-2 (human)

Ref: 01-4025474

Defensin HNP-2 (human) trifluoroacetate salt

Ref: 3D-FD110367