CAS: 12087-33-6

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Decitabine is a drug product that is being developed for the treatment of cancer. It has been shown to inhibit the proliferation of human tumor cells in vitro and to induce apoptosis in prostate cancer cells. Decitabine is metabolized to an active form, dideoxycitidine (DDC), which binds to DNA and inhibits the enzyme DNA polymerase alpha, leading to inhibition of DNA synthesis. Impurity 13 is a by-product of the synthesis process and can be used as an analytical standard. It can also be used as a research and development impurity standard or as a pharmacopoeia impurity standard.