CAS 121250-06-4: 14-chlorodaunorubicin

14-Chloro daunorubicin is a chemotherapeutic agent, which is a synthetic derivative of the naturally occurring anthracycline antibiotic, daunorubicin. This compound is specifically modified to include a chlorine atom at the 14th position, which enhances its pharmacological effectiveness compared to its parent compound. The drug acts primarily by intercalating into DNA, disrupting the function of topoisomerase II, and generating free radicals. These mechanisms collectively inhibit DNA replication and transcription, leading to cell apoptosis, particularly in rapidly dividing cancer cells. 14-Chloro daunorubicin is used extensively in scientific research for its potential therapeutic applications in oncology. Researchers explore its efficacy and safety profiles in various cancer models, particularly acute leukemias and other hematological malignancies. This compound helps in understanding the cellular responses to anthracycline derivatives and is pivotal in the development of more effective cancer treatments. Its unique structural modifications provide insight into the design of next-generation chemotherapy agents.