![N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenami…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F405723-n-3-5-chloro-2-4-4-methyl-1-piperazinyl-phenyl-amino-4-pyrimidinyl-thio-phenyl-2-propenamide.webp&w=3840&q=75)
CAS 1214265-57-2: N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide
Formula:C24H25ClN6OS
InChI:InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
InChI key:InChIKey=KIISCIGBPUVZBF-UHFFFAOYSA-N
SMILES:S(C1=NC(NC2=CC=C(C=C2)N3CCN(C)CC3)=NC=C1Cl)C4=CC(NC(C=C)=O)=CC=C4
Synonyms:- 2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-
- N-[3-[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide
- N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide
- Wz-8040
- Wz8040
Sort by
Found 4 products.
WZ8040
CAS:WZ8040 is a factor receptor inhibitor that blocks the epidermal growth factor receptor (EGFR) family of tyrosine kinase receptors. It is an inhibitor of the EGFR family of tyrosine kinases and has been shown to inhibit proliferation in vitro and in vivo. WZ8040 also inhibits the activation of downstream signaling pathways, including ERK, AKT, and STAT3, which regulate cell survival and proliferation. This drug has been shown to be effective against bladder cancer cells with wild-type EGFR but not those that are resistant to quinazoline-based drugs such as PD168393 or pelitinib.Formula:C24H25ClN6OSPurity:Min. 95%Molecular weight:481.01 g/molWZ8040
CAS:WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).Formula:C24H25ClN6OSPurity:97.42%Color and Shape:SolidMolecular weight:481.01
