CAS 121548-04-7: gelucire 44-14

Gelucire 44/14 is a pluronic block copolymer composed of a polyoxyethylene-polyoxypropylene glycol with an acyl chain. It is used as an absorption enhancer and excipient in pharmaceuticals, especially for small-molecule drugs that are not water-soluble. The drug is dispersed as particles and mixed with crystalline cellulose (CC) to produce a uniform mixture that is then compressed into tablets or capsules. CC acts as an antiadherent, preventing the adhesion of the drug particles to each other during compression. Gelucire 44/14 also has the ability to inhibit enzymes that are involved in lipid metabolism and prostaglandin synthesis.

Fatty substances of animal or vegetable orgin and mixtures thereof not elsewhere specified or included

Gelucire 44/14 (Gelucire 14/44) acts as a nonionic surface-active excipient and improves fat absorption in rats with impaired lipolysis.