CAS: 1217623-74-9
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Found 6 products.
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, hydrochloride (1:1), rel-
CAS:Formula:C16H18BrCl2N3O3Color and Shape:SolidMolecular weight:451.1424Halofuginone hydrochloride
CAS:Halogenated derivative of febrifugine; coccidiostatFormula:C16H17BrClN3O3·HClPurity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:451.14 g/molHalofuginone-13C,15N2 Hydrochloride
CAS:Controlled ProductFormula:CC15H17BrCl15N2NO3·HClColor and Shape:NeatMolecular weight:454.122Halofuginone Hydrochloride
CAS:Controlled ProductFormula:C16H17BrClN3O3·ClHColor and Shape:Colourless SolidMolecular weight:451.14Halofuginone hydrochloride
CAS:Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.Formula:C16H18BrCl2N3O3Color and Shape:SolidMolecular weight:451.14
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