CAS: 1219032-18-4

9-Keto Fluprostenol Isopropyl Ester, an ester derivative of the FP receptor agonist fluprostenol, undergoes oxidation at carbon 9. This compound serves as a potential prodrug for 9-keto fluprostenol, which may function as an agonist at EP receptors. Additionally, it is considered a possible metabolite of fluprostenol isopropyl ester (travoprost), drawing parallels to the metabolism of latanoprost by 15-hydroxyprostaglandin dehydrogenase observed in monkey cornea. Furthermore, certain F-series prostaglandins, such as 6-keto prostaglandin F1α (PGF1α), undergo conversion to their E-series counterparts in isolated human platelets, highlighting a metabolic pathway of relevance.

Applications 9-Keto Travoprost is an impurity of Travoprost (T715600), a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2). References Hellberg, M. R., et al.: J. Ocul. Pharmacol. Ther., 17, 421 (2001)