MK-3697, with the CAS number 1224846-01-8, is a chemical compound that has been studied primarily for its potential therapeutic applications. It is classified as a selective antagonist of the neurokinin-1 (NK1) receptor, which is involved in various physiological processes, including pain perception, mood regulation, and the stress response. The compound's structure typically features a complex arrangement of functional groups that contribute to its biological activity and selectivity. MK-3697 has been investigated in the context of treating conditions such as anxiety and depression, as well as for its potential role in managing pain. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile in clinical settings. As with many investigational drugs, ongoing research is essential to fully understand its mechanisms of action, therapeutic potential, and any associated side effects.

MK-3697

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MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).

MK-3697 is a research chemical that has shown various biological effects in bioassays. It has been found to reduce urea nitrogen levels and increase gamma-aminobutyric acid (GABA) concentrations, indicating its potential in the treatment of hepatic steatosis. MK-3697 has also demonstrated inhibitory activity against adenine-induced liver fibrosis, suggesting its role in preventing liver damage. Additionally, this compound exhibits triterpenoid saponin-like properties and may have applications in the development of new therapeutic agents. The ultra-low glycine amide content of MK-3697 makes it suitable for molecular docking studies and recrystallization experiments. Furthermore, MK-3697 has been investigated for its interaction with the 5-hydroxytryptamine subtype receptor, providing insights into its potential as a modulator of serotonin signaling pathways.

CAS 1224846-01-8: MK-3697

MK-3697

Ref: 54-BUP02586

MK-3697

Ref: TM-T1913

MK-3697

Ref: 3D-ZYB84601

[2,3'-Bipyridine]-4-carboxamide, N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-

Ref: IN-DA0017AJ