CAS 122872-03-1: Azuleno[6,5-b]furan-2(3H)-one,decahydro-5-hydroxy-4a,8-dimethyl-3-methylene-, [3aR-(3aa,4ab,5b,7aa,8a,9ab)]-

2-Desoxy-4-epi-pulchellin is a ribosome-inactivating protein (RIP), which is derived from the seeds of plant species, particularly within the Euphorbiaceae family. These proteins possess unique enzymatic activity that specifically targets and inactivates eukaryotic ribosomes by removing an adenine residue from the ribosomal RNA. This action halts protein synthesis, thereby inhibiting cell growth and proliferation. The primary utility of 2-Desoxy-4-epi-pulchellin is in the field of biochemical research, particularly in studies focusing on protein synthesis and cellular metabolism. Its ability to inhibit ribosomal function allows scientists to explore the underlying mechanisms of translation and to study the cellular responses to inhibited protein production. Additionally, due to its potent cytotoxic effects, this RIP is being explored for therapeutic applications, particularly in the targeted treatment of cancerous cells where selective inhibition of protein synthesis could be beneficial. Research into the mechanisms and potential applications of 2-Desoxy-4-epi-pulchellin continues to provide valuable insights in molecular biology and therapeutic development.

2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with

2-Desoxy-4-epi-pulchellin