CAS 122955-13-9: 9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-, dihydrochloride

XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker.

XE991 Dihydrochloride

XE 991 dihydrochloride is a small molecule inhibitor, which is an experimental compound used primarily in neuroscience research. It is sourced synthetically and serves as a specific and selective blocker of the K_v7/M (KCNQ) potassium channels. The mode of action of XE 991 dihydrochloride involves binding to these channels, thereby inhibiting their activity and preventing potassium ion flow across neuronal membranes. This results in changes to neuronal excitability and membrane potential. XE 991 dihydrochloride is utilized in various applications to study the physiological roles of the K_v7/M channels and to explore their potential as therapeutic targets. Its use is particularly prominent in experiments investigating neuronal signaling, epilepsy, and other conditions related to hyperexcitability. Researchers employ this compound to dissect the contributions of specific channel subunits and pathways in maintaining neuronal homeostasis. The specificity and potency of XE 991 dihydrochloride make it a valuable tool for delineating the pharmacological and functional properties of potassium channels in both in vitro and in vivo studies.

XE 991 dihydrochloride