CAS: 1233152-82-3

Guangxitoxin 1E is a peptide toxin, which is derived from the venom of the tarantula species *Plesiophrictus guangxiensis*. This toxin targets voltage-gated potassium channels, specifically the Kv2.1 channels, by inhibiting their normal function. The mode of action involves binding to these channels, which disrupts the flow of potassium ions across the cell membrane, ultimately affecting neuronal excitability and signaling. Guangxitoxin 1E is of significant interest in neurophysiological research and pharmacology. It is utilized to study the structure and function of ion channels, which are crucial for various cellular processes. Understanding how Guangxitoxin 1E affects potassium channels can provide insights into the development of therapeutic agents for neurological disorders and conditions that involve dysregulated ion channels. Its specificity and potency make it a valuable tool in the elucidation of ion channel mechanisms and in the exploration of new drug targets.

Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.

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