CAS 123359-42-2: Sulfobromophthalein sodium

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Sulfobromophthalein disodium salt hydrate is a fluorescent chemical that is used as a marker for renal function. It is most commonly used to assess the function of proximal tubules in the kidney and to assess the presence of cancer cells in various tissues. The uptake of sulfobromophthalein by the renal proximal tubules can be measured with an assay involving caco-2 cells. Multidrug resistance-associated protein (MRP) and other efflux pumps are expressed in these cells, which limits the amount of drug that can be absorbed into the cell. MRP also plays a role in multidrug resistance by pumping drugs back out of cells into the extracellular fluid, preventing them from being reabsorbed into circulation. This causes higher concentrations of drugs to accumulate inside the cell, leading to apoptosis. Sulfobromophthalein has been shown to attenuate cancer progression, as well as reduce multidrug resistance