CAS: 1234319-68-6

TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.

TAK-448 is a peptide that inhibits the activation of ion channels. It binds to the ligand binding site of ion channels and blocks the passage of ions, thereby inhibiting the function of these proteins. TAK-448 has been shown to inhibit potassium, calcium, and sodium channels in vitro. This inhibitor also has an antagonist effect on GABA-A receptors in vivo. TAK-448 is a reagent for research in cell biology, pharmacology, and other fields. It can be used as a standard tool to study protein interactions or as an activator for receptor studies. TAK-448 is provided at high purity (greater than 99%) with no detectable contaminants.