CAS: 1238697-26-1

Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.

1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TFPP) is an orally active, potent inhibitor of the enzyme guanosine deaminase that has been shown to be effective in animals with asperger syndrome. TFPP also interacts with other enzymes such as amines and can cause hyperlocomotion in rats. The drug has a high potency for inhibiting the enzyme guanosine deaminase, which is involved in the synthesis of purines. TFPP has a chlorine atom at position 5, which may be important for its inhibitory activity. The most potent inhibitors of this type have a fluorine atom at this position. In addition, TFPP has a carbonyl group at position 2 that may

Balipodect

1-(2-Fluoro-4-(1H-Pyrazol-1-Yl)Phenyl)-5-Methoxy-3-(1-Phenyl-1H-Pyrazol-5-Yl)Pyridazin-4(1H)-One