Topotecan Carboxylic Acid Sodium Salt, with the CAS number 123949-08-6, is a water-soluble derivative of topotecan, a camptothecin analog used primarily in cancer therapy. This compound exhibits antitumor activity by inhibiting topoisomerase I, an enzyme crucial for DNA replication and transcription. The sodium salt form enhances its solubility, making it more suitable for intravenous administration. Characteristically, it is a white to off-white powder that is hygroscopic and stable under proper storage conditions. The compound is typically characterized by its molecular formula, which reflects the presence of both carboxylic acid and sodium components. Its pharmacological profile includes a mechanism of action that leads to the induction of apoptosis in cancer cells, making it effective against various malignancies, particularly ovarian and small cell lung cancers. Additionally, it has a defined pH range for optimal stability and activity, and its formulation may include excipients to enhance bioavailability and patient tolerability.

Topotecan Carboxylic Acid Sodium Salt

123949-08-6: 1-[(Dimethylamino)methyl]-a-ethyl-9,11-dihydro-a,2-dihydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Monosodium Salt

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Topotecan carboxylic acid sodium salt

Indolizino[1,2-b]quinoline-7-acetic acid, 1-[(dimethylamino)methyl]-α-ethyl-9,11-dihydro-α,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt, (S)- (9CI)

CAS 123949-08-6: Topotecan Carboxylic Acid Sodium Salt

Topotecan carboxylic acid sodium salt

Ref: 3D-FT28328

Topotecan Carboxylic Acid Sodium Salt

Ref: 4Z-T-268

Indolizino[1,2-b]quinoline-7-acetic acid, 1-[(dimethylamino)methyl]-α-ethyl-9,11-dihydro-α,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt, (S)- (9CI)

Ref: IN-DA000L9D