CAS 1241-94-7: 2-Ethylhexyl diphenyl phosphate

2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.

2-Ethylhexyl diphenyl phosphate (2-EHDP) is a fatty acid that is used as a plasticizer or lubricant additive. It has been shown to cause chronic locomotor activity and thermal expansion in mice, with the effects on locomotor activity being more pronounced after long-term exposure. 2-EHDP has also been shown to inhibit the polymerase chain reaction (PCR) in vitro and to produce tumorigenicity in vivo, although it does not appear to be carcinogenic. 2-EHDP does not affect 3T3-L1 preadipocytes but reduces the viability of human serum and human cells, which may be due to its ability to interfere with lipid metabolism.

Applications 2-Ethylhexyl Diphenyl Phosphate can be used as a flame retardant, an additive or a plasticizer for resins. It is considered as an emerging contaminant. References Pang, L., et al.: Envir. Toxicol. Chem., 32, 2755 (2013); Yang, F., et al.: Envir. Sci. Technol., 48, 63 (2014); Sundkvist, A., et al.: J. Envir. Monitor., 12, 943 (2010)

2-Ethylhexyl diphenyl phosphate