CAS: 1255386-16-3

Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.

Applications Regorafenib-d3 is the isotope labelled analog of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM and is useful for the treatment of inflammation. Also an anti-proliferative agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)

Regorafenib-d3 is a synthetic, high purity, fluorescent analog of regorafenib. It is a potent inhibitor of the receptor tyrosine kinase, RET. This drug has been shown to inhibit RET with an IC50 of 0.1 nM in vitro and inhibits proliferation in cell culture assays. It is also an agonist for the ion channel TRPV4 and can be used as a research tool for investigating protein interactions.