CAS: 1256349-48-0

Chiauranib is a potent and selective inhibitor of the ion channel TRPM2. It blocks the influx of calcium ions into cells, which leads to cell death. Chiauranib is also an inhibitor of the receptor-ligand interactions of corticotropin-releasing hormone (CRH) and vasopressin with CRH receptors, leading to the inhibition of their biological effects. This compound has been shown to be a high-quality research tool for pharmacology and protein interactions involving peptides. Chiauranib has not been shown to have any antibody reactivity or cytotoxicity in cell culture.

Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.

Chiauranib