CAS: 1259330-61-4

Sparstolonin B is a natural anti-inflammatory compound, which is derived from the Chinese herb *Sparganium stoloniferum*. It primarily functions as a selective antagonist of Toll-like receptors 2 and 4 (TLR2 and TLR4), thereby inhibiting the activation of these pathways which are crucial in mediating inflammatory responses. The compound's mode of action involves blocking the signaling cascades initiated by the binding of pathogen-associated molecular patterns to TLRs, which prevents the subsequent production of inflammatory cytokines. Due to its unique mechanism, Sparstolonin B has garnered interest for potential therapeutic applications in treating conditions characterized by excessive inflammation, such as cardiovascular diseases, certain cancers, and autoimmune disorders. Furthermore, its herbal origin provides a distinct advantage for scientists researching non-synthetic anti-inflammatory agents. This compound's capability to modulate immune responses highlights its potential as a valuable tool in both experimental research and future therapeutic development.

Sparstolonin B is a TLR2 and TLR4 antagonist with anti-HIV, anti-cancer, anti-tumor and anti-inflammatory activities,.

Sparstolonin B