CAS 1268524-70-4: JQ 1(+)
Formula:C23H25ClN4O2S
InChI:InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChI key:InChIKey=DNVXATUJJDPFDM-KRWDZBQOSA-N
SMILES:CC=1C2=C(N3C([C@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
Synonyms:- (+)-Jq1
- (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- (S)-Jq1
- 1,1-Dimethylethyl (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
- 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
- BET domain inhibitor JQ1
- Bromodomain and extra-terminal domain inhibitor JQ1
- JQ1 (BET inhibitor)
- JQ1 (pharmaceutical)
- Jq-1
- tert-Butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
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Found 7 products.
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
CAS:Formula:C23H25ClN4O2SPurity:98%Color and Shape:SolidMolecular weight:456.9882Ref: IN-DA000TCZ
1g171.00€5g557.00€10gTo inquire25gTo inquire50gTo inquire100gTo inquire10mg30.00€25mg49.00€50mg50.00€100mg71.00€250mg113.00€500mg149.00€(S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
CAS:Applications BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. References Li, Z.C., et al.: Nuc. Acids. Res., 41, 277 (2013); Hay, D., et al.: Med. Chem. Comm., 4, 140 (2013);Formula:C23H25ClN4O2SColor and Shape:Light Yellow SolidMolecular weight:456.99(+)-JQ-1
CAS:(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.Formula:C23H25ClN4O2SPurity:97.57% - ≥95%Color and Shape:SolidMolecular weight:456.99Ref: TM-T2110
1mg35.00€2mg44.00€5mg60.00€10mg79.00€25mg96.00€50mg144.00€100mg188.00€200mg283.00€500mg512.00€1mL*10mM (DMSO)66.00€(+)-JQ 1
CAS:Controlled ProductPotent BET inhibitor with high specificity for acetyl-lysine recognition motifs found in the BET family (Brd2, Brd3, Brd4, Brdt). Engages with bromodomain pocket and competes with acetylated peptide binding, causing displacement of BET proteins from chromatin and disrupting transcription. Has been used in clinical trials as chemotherapy and male contraceptive.Formula:C23H25ClN4O2SPurity:Min. 95%Color and Shape:White PowderMolecular weight:456.99 g/mol
![6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trime…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000TCZ.jpg&w=3840&q=75)
![(S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb%2FT117580.jpg&w=3840&q=75)
