![1,1-Dimethylethyl (6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fcas-image%2Fthumb-webp%2F31590-11-dimethylethyl-6r-4-4-chlorophenyl-239-trimethyl-6h-thieno-32-f-124-triazolo-43-a-14-diazepine-6-acetate.webp&w=3840&q=75)
CAS 1268524-71-5: 1,1-Dimethylethyl (6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
Formula:C23H25ClN4O2S
InChI:InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1
InChI key:InChIKey=DNVXATUJJDPFDM-QGZVFWFLSA-N
SMILES:CC=1C2=C(N3C([C@@H](CC(OC(C)(C)C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
Synonyms:- 1,1-Dimethylethyl (6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
- (R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- JQ 1(-)
- 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
- (-)-JQ 1
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Found 6 products.
(-)-JQ1
CAS:Controlled Product(-)-JQ1 is a small molecule inhibitor of the CDK4/6 complex that has been shown to be synergistic with palbociclib for the treatment of hematological malignancies. (-)-JQ1 has also been shown to inhibit proliferation and induce apoptosis in multiple myeloma cells, which may be due to its ability to bind to the bromodomain and interfere with transcriptional activity. (-)-JQ1 is a pan-histone deacetylase inhibitor that can cause dose-dependent changes in gene expression. It targets proapoptotic genes such as Bim and Bmf, while upregulating antiapoptotic genes such as p21 and Mcl-1. (-)-JQ1 is an analog of JQ1, which was originally discovered by screening a synthetic compound library for inhibitors of histone acetylation.Formula:C23H25ClN4O2SPurity:Min. 95%Molecular weight:456.99 g/mol6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
CAS:Formula:C23H25ClN4O2SPurity:98%Color and Shape:SolidMolecular weight:456.9882Tert-Butyl (R)-2-(4-(4-Chlorophenyl)-2,3,9-Trimethyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepin-6-Yl)Acetate
CAS:Tert-Butyl (R)-2-(4-(4-Chlorophenyl)-2,3,9-Trimethyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepin-6-Yl)AcetatePurity:98%Molecular weight:456.99g/mol(R)-(-)-JQ1 Enantiomer
CAS:(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)Formula:C23H25ClN4O2SPurity:99.38%Color and Shape:SolidMolecular weight:456.99(R)-(-)-tert-Butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
CAS:Controlled ProductFormula:C23H25ClN4O2SColor and Shape:NeatMolecular weight:456.988
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![(R)-(-)-tert-Butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb%2FT117585.jpg&w=3840&q=75)
