CAS: 1270084-92-8

Apx-115 is a small molecule compound, which acts as a selective inhibitor derived from pharmacological synthesis with targeted cellular mechanisms. It functions through the inhibition of specific enzymatic pathways that regulate oxidative stress responses and inflammation pathways in cells. The precise mode of action includes modulating the activity of enzymes involved in redox signaling, potentially impacting the regulation of reactive oxygen species (ROS) and associated cellular processes. Apx-115 is utilized in various biomedical research applications, particularly in studies focused on understanding and treating conditions related to oxidative stress and chronic inflammatory states. Its ability to selectively target and modulate key pathways provides an invaluable tool for scientists exploring disease mechanisms, potential therapeutic targets, and the development of new treatments. Researchers may employ Apx-115 to investigate the molecular underpinnings of diseases such as neurodegenerative disorders, cardiovascular conditions, and metabolic syndromes, seeking insights into innovative intervention strategies. Its specificity and effectiveness make it a critical component in experimental models and mechanistic studies.

APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM

APX-115 free base