Tetrofosmin is a chemical compound primarily used as a radiopharmaceutical in medical imaging, particularly in myocardial perfusion imaging. It is a lipophilic cationic compound that facilitates the visualization of cardiac tissues by accumulating in viable myocardial cells. Tetrofosmin is characterized by its ability to cross cell membranes due to its lipophilic nature, allowing it to concentrate in areas with high metabolic activity, such as healthy heart tissue. The compound is typically administered intravenously and is labeled with a radioactive isotope, commonly technetium-99m, which enables its detection through gamma cameras during imaging procedures. Tetrofosmin is known for its favorable pharmacokinetics, including rapid clearance from the bloodstream and minimal retention in non-target tissues, which enhances the quality of the imaging results. Additionally, it has a good safety profile, with a low incidence of adverse effects, making it a valuable tool in the assessment of coronary artery disease and other cardiac conditions.

Tetrofosmin

127502-06-1: 3,12-Dioxa-6,9-diphosphatetradecane, 6,9-bis(2-ethoxyethyl)-, 6,9-Bis(2-Ethoxyethyl)-3,12-Dioxa-6,9-Diphosphatetradecane, Ethylenebis(bis(2-ethoxyethyl)phosphine), Technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane, Tetrofosmin [USAN:INN:BAN:JAN], Unii-3J0Kpb596Q, P 53 (tetrofosmin), Tetrofosmin

3,12-Dioxa-6,9-diphosphatetradecane, 6,9-bis(2-ethoxyethyl)-

Tetrofosmin is a fluorinated analog of the natural pyrimidine nucleotide hypoxanthine. It is used in the diagnosis and treatment of cardiac disorders such as myocardial infarct, congestive heart failure, or hyperproliferative diseases. Tetrofosmin is administered intravenously and binds to DNA in hypoxic cells, which leads to increased production of oxygen-carrying hemoglobin (Hb) and restoration of mitochondrial membrane potential. This process increases cellular oxygenation and reduces tissue damage due to lack of oxygen. Tetrofosmin also has anti-cancer properties, as it inhibits proliferation in tumor cells by binding to DNA gyrase.

Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.

CAS 127502-06-1: Tetrofosmin

Tetrofosmin

Ref: TR-T309530

3,12-Dioxa-6,9-diphosphatetradecane, 6,9-bis(2-ethoxyethyl)-

Ref: IN-DA000X4O

Tetrofosmin

Ref: 3D-CFA50206

Tetrofosmin

Ref: TM-T34830