PF-4989216, identified by its CAS number 1276553-09-3, is a chemical compound that has garnered attention in pharmaceutical research, particularly for its potential therapeutic applications. It is characterized as a small molecule inhibitor, specifically targeting certain protein interactions that are crucial in various biological pathways. The compound is often studied for its role in modulating cellular processes, which may have implications in treating diseases such as cancer or other conditions where these pathways are dysregulated. In terms of its physical properties, PF-4989216 may exhibit specific solubility, stability, and reactivity profiles that are typical of small organic molecules. Its structure likely includes functional groups that facilitate interactions with biological targets, contributing to its efficacy and selectivity. As with many investigational compounds, detailed studies on its pharmacokinetics, toxicity, and overall biological activity are essential for understanding its potential as a therapeutic agent.

PF-4989216

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PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.

PF-4989216 is a small-molecule drug that has potent antitumor activity in vivo and in vitro. This compound binds to the ATP binding site of ABCB1 and ABCG2 transporters, which are responsible for the efflux of anticancer drugs from cancer cells. PF-4989216 also inhibits multidrug resistance by inhibiting the function of P-glycoprotein (Pgp) and MRP1. This agent is currently in clinical development as a potential treatment for cancer.

CAS 1276553-09-3: PF-4989216

PF-4989216

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PF-4989216

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PF-4989216

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PF-4989216

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