CAS: 1279026-26-4

Benazepril is a pharmaceutical drug that belongs to the group of model drugs. It is a prodrug, which undergoes bioactivation in vivo to benazeprilat, its active form. Benazepril is used as a treatment for high blood pressure and congestive heart failure. The concentration of benazepril in plasma can be measured using an ionization mass spectrometer (IMS) with an inorganic method or a liquid chromatography-mass spectrometer (LC-MS). The IMS technique uses deuterated benazepril as the internal standard and calibrates the instrumentation parameters with this compound. A calibration curve is then constructed from the standards and applied to samples that are analyzed by LC-MS. This calibration curve can be used for quantitation of benazepril at low levels.

Applications Benazepril-d5 Hydrochloride is the labeled analogue of Benazepril Hydrochloride (B119750), which is used as an antihypertensive; angiotensin converting enzyme inhibitor. References Schaller, M.D., et al.: Eur. J. Clin. Pharmacol., 28, 267 (985); Colfer, H.T., et al.: Am. J. Cardiol., 70, 354 (1992)