dl-2-Amino-4-methyl-5-phosphono-3-pentenoic acid, commonly referred to as AMPA, is a synthetic amino acid derivative that acts as a potent agonist of the glutamate receptor, specifically targeting the AMPA subtype. This compound is characterized by its unique structure, which includes an amino group, a phosphono group, and a pentenoic acid backbone. It is typically a white to off-white crystalline powder that is soluble in water, making it suitable for various biochemical applications. AMPA plays a significant role in neurobiology, particularly in studies related to synaptic transmission and plasticity, as it mimics the action of glutamate, the primary excitatory neurotransmitter in the central nervous system. Its ability to modulate neuronal activity makes it a valuable tool in research on learning, memory, and neurodegenerative diseases. Additionally, due to its phosphono group, it can participate in various chemical reactions, contributing to its utility in synthetic organic chemistry and pharmacological studies.

dl-2-amino-4-methyl-5-phosphono-3-*pentenoic acid

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CGP 37849 is an antagonist of the NMDA receptor. It has been shown to inhibit the transcriptional regulation of human dopamine-producing neurons in culture, with a potency that was 3-fold greater than that of MK801. CGP 37849 is also an antagonist of the NMDA receptor and can be used for the treatment of Parkinson's disease. This drug inhibits glutamate release from neurons and may act by blocking or reversing calcium channels or by inhibiting cation channels. CGP 37849 has been shown to increase locomotor activity and improve performance on a rotarod test in rats. The histological analysis showed neuronal death, which was prevented when CGP 37849 was administered prior to administration of neurotoxins.

CGP 37849

CGP 37849: oral NMDA antagonist (Ki=35 nM), anticonvulsant, with antidepressant/anxiolytic effects.

CAS 127910-31-0: dl-2-amino-4-methyl-5-phosphono-3-*pentenoic acid

CGP 37849

Ref: 3D-CFA91031

CGP 37849

Ref: TM-T7720

3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-

Ref: IN-DA000H8C

CGP 37849

Ref: 54-BUP02982