CAS 128013-69-4: 3-(Aminomethyl)-5-methylhexanoic acid

Applications A GABA analogue used as an anticonvulsant.Controlled substance in the United States.Not controlled in Germany References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)

Applications Isotope labelled rac-Pregbalin, a GABA analogue used as an anticonvulsant. References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)

Applications 4-Isobutyl-1'-methyl-1,2'-bipyrrolidin-2-one is an impurity of pregabalin (P704800), which is a GABA analogue used as an anticonvulsant.Controlled substance in the United States.Not controlled in Germany References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)

Rac-pregabalin is a carboxylate prodrug of the GABA analog pregabalin. It is an agonist at the alpha2 delta receptor, which is a major inhibitory neurotransmitter in the central nervous system. Rac-pregabalin has high affinity binding to this receptor and has been shown to be more potent than gabapentin. It also binds to other receptors, including the GABA-B receptor and benzodiazepine site on the GABAA receptor. Rac-Pregabalin enhances GABAergic neurotransmission by interacting with these receptors and increasing their ability to bind GABA.