CAS 128315-56-0: melanin concentrating hormone rat

MCH(human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors. MCH increases food intake in vivo.

Melanin Concentrating Hormone

Bachem ID: 4025037.

Melanin concentrating hormone (MCH) is a peptide that belongs to the family of neuropeptides. It has been shown to be involved in the regulation of food intake and energy metabolism. MCH stimulates the release of gamma-aminobutyric acid (GABA) from neurons, which may account for its inhibitory effects on locomotor activity, neuronal function, and brain functions. MCH is also a potent stimulator of cyclic adenosine monophosphate (cAMP) production in hepatocytes, leading to hepatic steatosis. MCH binds with high affinity to its receptor in the hypothalamus and pituitary gland.

Melanin-concentrating hormone (MCH) is a neuropeptide that is used to study the regulation of food intake and body weight. MCH binds to its receptor, the melanocortin-4 receptor (MC4R), which is coupled to an ion channel. This binding causes the release of potassium ions from cells, leading to depolarization and increased neuronal excitability. It has been shown that MCH can be used as a research tool for studying ion channels, ligand-receptor interactions, and cell biology.