CAS 129-06-6: (±)-Warfarin sodium

WARFARIN SODIUM CRS

3-(α-Acetonylbenzyl)-4-hydroxycoumarin sodium is an anticoagulant compound, which is a synthetic derivative of coumarin. It is primarily sourced via chemical synthesis in laboratory settings. Its mode of action involves inhibiting the synthesis of vitamin K-dependent clotting factors, specifically factors II, VII, IX, and X. This inhibition impairs blood coagulation, leading to uncontrolled bleeding. The primary use of 3-(α-Acetonylbenzyl)-4-hydroxycoumarin sodium is in the field of pest control, where it is employed as a rodenticide. The compound is particularly valuable in managing populations of rodents such as rats and mice, which are significant agricultural and urban pests. It is typically formulated into bait products that are ingested by the target species, leading to effective population reduction due to its delayed action mechanism. This delay ensures that the rodent does not associate the adverse effects with the bait, thereby increasing the likelihood of ingestion by other members of the population. While highly effective, handling and application require careful management due to potential hazards to non-target species and the risk of secondary poisoning.

Applications (±)-Warfarin Sodium, an anticoagulant drug product. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nguyenpho, A., et al.: J. Pharm. Sci., 104, 4232-4240, (2015)

Warfarin sodium

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.