CAS: 1304701-57-2

Stability Hygroscopic Applications Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor. References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)

Edoxaban-d6 is a nonsteroidal anti-inflammatory drug that belongs to the group of platelet aggregation inhibitors. It is used to prevent blood clots and stroke in patients with atrial fibrillation. Edoxaban-d6 is a prodrug that needs to be converted into its active form by esterases in the body before it can act. This conversion process involves hydrolysis of the ester moiety and opening of the lactam ring. The metabolism of edoxaban-d6 has been shown to be age dependent, with older subjects having lower levels of esterase activity than younger subjects.