CAS 130848-06-5: Decursinol angelate

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(S)-8,8-Dimethyl-2-Oxo-7,8-Dihydro-2H,6H-Pyrano[3,2-G]Chromen-7-Yl (Z)-2-Methylbut-2-Enoate

Decursinol angelate is a bioactive compound, which is derived from the roots of plants such as Angelica gigas, a species commonly used in traditional Asian medicine. This compound is a coumarin derivative, known for its potential pharmacological properties. Decursinol angelate’s mode of action involves the modulation of inflammatory pathways, particularly through the inhibition of key enzymes and cytokines involved in inflammatory responses, such as COX-2 and TNF-alpha. This modulation leads to a reduction in the synthesis of pro-inflammatory mediators, which can be beneficial in managing inflammation-related conditions. The uses and applications of Decursinol angelate span a range of biomedical fields, particularly in the development of anti-inflammatory therapies. It has been studied for its potential efficacy in treating conditions such as arthritis and other auto-immune disorders. Additionally, due to its origin and mode of action, it may serve as a template for the synthesis of new therapeutic agents aiming to mitigate inflammatory processes. Researchers are exploring its role in broader pharmacological contexts, leveraging its natural origin and biological activity to enhance health outcomes.

Decursinol angelate

Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.Decursinol angelate has protective effects against amyloid β-protein-induced oxidative stress in the PC12 cell line. It improves wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors. Decursinol angelate has in vitro and in vivo antifungal activity against Magnaporthe oryzae, the causal agent of rice blast.

Lactone

Decursinol angelate is anti-tumor, anti-inflammatory, anti-oxidant, hepatoprotective, and inhibits VEGF and cancer cell invasion.