CAS 131147-81-4: Hirullin

Hirullin, originally isolated from the leech Hirudinaria manillensis, is a hirudin-based fibrinogen recognition peptide inhibitor, which binds efficiently to thrombin (IC₅₀= 4.2 µM, in bovine).

Hirullin H-Ser-Asp-Phe-Glu-Glu-Phe-Ser-Leu-Asp-Asp-Ile-Glu-Gln is a peptide with a carboxy terminal and carbonyl group. It has minimal inhibitory concentrations of about 100 nM for most bacteria and is active against the majority of Gram positive bacteria. Hirullin H is composed of amino acid sequences that are similar to the sequences of active substances in other compounds, such as hirulog, an anticoagulant, and heparin, an antithrombotic drug. Hirullin H has been shown to have bifunctional properties by inhibiting thrombin, which is responsible for blood clotting, while also inhibiting platelet activation.

Hirullin P18 is a potent thrombin inhibitor with anticoagulant properties [1].