Metronidazole acetate, with the CAS number 13182-82-6, is a derivative of metronidazole, an antibiotic commonly used to treat various infections, particularly those caused by anaerobic bacteria and protozoa. This compound typically appears as a white to off-white crystalline powder and is soluble in organic solvents such as ethanol and methanol, but has limited solubility in water. The acetate moiety enhances its pharmacokinetic properties, potentially improving absorption and bioavailability. Metronidazole acetate retains the antimicrobial activity of its parent compound, making it effective against a range of pathogens. It is important to note that, like other nitroimidazole derivatives, it may exhibit side effects, including gastrointestinal disturbances and potential neurotoxicity with prolonged use. The compound's mechanism of action involves the reduction of its nitro group, leading to the formation of reactive intermediates that damage bacterial DNA. As with any pharmaceutical, its use should be guided by appropriate medical advice and consideration of resistance patterns in target pathogens.

Metronidazole acetate

13182-82-6: 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, 1-acetate, 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, acetate (ester), 2-Methyl-5-nitro-1H-imidazole-1-ethanol acetate (ester), Imidazole-1-ethanol, 2-methyl-5-nitro-, acetate, Imidazole-1-ethanol, 2-methyl-5-nitro-, acetate (ester), Metronidazole acetate, O-Acetylmetronidazole

O-Acetylmetronidazole

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Applications Metronidazole Acetate is a protected Metronidazole (M338880). Metronidazole Acetate is an imidazole derivative with anti-trichomonas, antifungal and spermicidal activity.
References Kumar, L. et al.: ACS Med. Chem. Lett., 3, 83 (2012); Kumar, L. et al.: Eur. J. Med. Chem., 45, 817 (2010)


CAS 13182-82-6: Metronidazole acetate

O-Acetylmetronidazole

Ref: TR-MM0012.11

Metronidazole acetate

Ref: 3D-NAA18282

O-Acetylmetronidazole

Ref: 86-MM0012.11

Metronidazole Acetate

Ref: TR-M338885