CAS: 1322544-82-0

Di-o-glycinoylcurcumin-d6 dihydrochloride is an isotopically labeled curcumin derivative, which is a compound used primarily in biochemical and pharmaceutical research. This product is synthesized in the laboratory, with deuterium atoms incorporated strategically to facilitate NMR spectroscopy studies and other analytical applications. The mode of action of Di-o-glycinoylcurcumin-d6 dihydrochloride involves the inhibition of cellular pathways by mimicking curcumin in biological systems. This isotopically labeled compound is valuable for tracing metabolic pathways and understanding the pharmacokinetics of curcuminoids in vitro or in vivo. As a tool in research, Di-o-glycinoylcurcumin-d6 dihydrochloride is utilized in studies focusing on antioxidant activity, anti-inflammatory processes, and cancer research. Its labeled structure allows scientists to analyze metabolic stability, absorption, and molecular interactions with high sensitivity, providing critical insights into the underlying mechanisms and potential therapeutic applications of curcumin-based therapies.

Applications Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disea References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)