CAS 132292-17-2: 2-Naphthalenecarboxylic acid, 6-(4-methoxyphenyl)-

6-(4-Methoxyphenyl)-2-naphthoic acid is a hydrophobic compound that binds to the monomer of the polyester with an interaction constant of K = 3.6 x 10 M. This interaction is due to its acidic character, which allows it to interact with the hydrophobic regions of the polyester's monomer. It also has an adapalene binding constant of K = 2.5 x 10 M and a molecular weight of 288.39 g/mol. 6-(4-Methoxyphenyl)-2-naphthoic acid can be used in liquid crystal and hydrolyzed suzuki coupling reactions as a synthetic intermediate for polyesters, such as poly(ethylene terephthalate) (PET).

Applications 6-(4-Methoxyphenyl)-2-naphthoic Acid is a reactant in the synthesis of Adapalene (A225000), a retinoid selective for retinoic acid receptor (RAR) subtypes β and γ. Antiacne. References Milanese, A., et. al.: Bioorg. Chem., 39, 151 (2011); Griffiths, C.E.M., et al.: J. Invest. Dermatol., 101, 325 (1993); Bernard, B.A., et al.: Skin Pharmacol., 6, 61 (1993); Waugh, J., et al.: Drugs, 64, 1465 (2004)