CAS 13268-67-2: senecionine N-oxide

Stability Hygroscopic Applications Senecionine N-oxide-D3 is a labelled analogue of Senecionine N-oxide (S258655Senecionine N-oxide is the major pyrrolizidine alkaloid in Senecio vulgaris, a native herb of the British Isles. Senecionine N-oxide is hepatotoxic, and is suspected to be an antifertility agent in rats. Despite its toxicity, it is also being regarded as an antiproliferative agent for tumour growth. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hartmann, T. & Toppel, G.: Phytochemistry, 26, 1639 (1987); Su, J., et al.: Org. Mag. Res., 11, 565 (1978); Tu, Z., et al.: J. Pharm. Sci., 77, 461 (1988)

Senecionine N-oxide is a pyrrolizidine alkaloid N-oxide, which is a naturally occurring chemical compound known for its toxicological properties. It is primarily sourced from plants belonging to the Senecio genus, which are widely distributed across various geographical regions. The mode of action of Senecionine N-oxide involves its bioactivation in the liver, where it is converted to reactive pyrrolic metabolites. These metabolites can form adducts with cellular macromolecules such as DNA and proteins, leading to hepatic necrosis and potentially mutagenic effects. Senecionine N-oxide is primarily studied in the field of toxicology to understand its impact on human health and livestock. It serves as a model compound for investigating the metabolic pathways and toxicological mechanisms of pyrrolizidine alkaloids. Additionally, it is used as a reference compound in analytical studies aiming to identify and quantify pyrrolizidine alkaloid contamination in food and herbal products. Understanding its mode of action and effects is crucial for developing risk assessment strategies and mitigation measures for exposure to pyrrolizidine alkaloid-containing plants.

Natural alkaloid

Senecionine N-oxide: biosynthesized in Trichoderma lucidum roots, has antitumor properties, but can cause liver syndrome.